منابع مشابه
Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator
OBJECTIVE To evaluate the role of SIRT1 in small intestine damage following severe hemorrhagic shock and to investigate whether polydatin (PD) can activate SIRT1 in shock treatment. RESEARCH DESIGN AND METHODS The severe hemorrhagic shock model was reproduced in Sprague Dawley rats. MAIN OUTCOME MEASURES Two hours after drug administration, half of the rats were assessed for survival time e...
متن کاملMucosal lesions in the human small intestine in shock.
Characteristic mucosal lesions in resected small intestinal segments from seven patients are reported. Preoperatively, four patients were in shock and general hypotension while the three remaining cases showed signs of local intestinal hypotension. The microscopic appearance of the mucosal lesions was in all patients identical with that previously observed in the feline and canine small intesti...
متن کاملHeterogeneous microcirculation in the rat small intestine during hemorrhagic shock: quantification of the effects of hypertonic-hyperoncotic resuscitation.
PURPOSE In the event of a spatial or temporal microvascular perfusion heterogeneity conventional methods are often inadequate to describe the microcirculatory changes. Our aim was to use a new formula to characterize and compare the microcirculatory reactions in the mucosa and longitudinal muscle of the rat small intestine in response to hypertonic/hyperoncotic and normotonic resuscitation stra...
متن کاملRemoval of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury
The small intestine plays a key role in the pathogenesis of multiple organ failure following circulatory shock. Current results show that reduced perfusion of the small intestine compromises the mucosal epithelial barrier, and the intestinal contents (including pancreatic digestive enzymes and partially digested food) can enter the intestinal wall and transport through the circulation or mesent...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1974
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(74)80053-3